BRAIN-IoT is establishing a framework and methodology that supports smart autonomous and cooperative behaviors of populations of heterogeneous IoT platforms that are also closely interacting with Cyber-Physical systems (CPS). BRAIN-IoT employs highly dynamic federations of heterogeneous IoT platforms, mechanisms enforcing privacy and data ownership policies as well as open semantic models enabling interoperable operations and exchange of data and control features. Brain-IoT also offers model-based tools easing the development of innovative, tightly integrated IoT and CPS solutions.